What is a NAM?

Understand what a NAM is, how in silico, in chemico, and in vitro methods qualify as New Approach Methodologies, and how they gain regulatory recognition as alternatives to animal testing.

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The acronym NAM (new approach method or novel alternative methodology) refers to an innovative *in silico*, *in chemico*, or *in vitro*-based scientific method for research and testing. They are intended to provide translatable research outcomes that are more relevant to human biology and disease than an animal model. Examples include human induced pluripotent stem cells, organoids and tumoroids, computational models, organ-on-a-chip technologies, and high-throughput screening methods. There must be a direct and demonstrable reduction in the use of animals for a methodology to be considered a NAM. Once validated to accurately recapitulate *in vivo* biology, NAMs will become increasingly recognized by regulatory agencies as viable options for research and testing.

Related NAM testing resources

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