Co-Development for NAM Testing

For investigators designing and developing New Approach Methodologies (NAMs), NAM testing at UC Davis offers NAM Co-Development Services to support the strategic planning, organization, and assembly of purpose-built NAMs with an emphasis on feasibility, functionality, and translational relevance. NAMs, conceived and developed entirely independent of the in vivo systems they aim to emulate, may overlook critical biological interactions essential to their application in biomedical research. Our Co-Development approach integrates biological and mechanistic context early in the design process, helping to prevent costly redesigns or delays later in development.

Our collaborative resources at UC Davis work directly with your team, providing expertise in complex biological systems and mechanistic pathways to guide the conceptualization and repurposing of your NAM. This includes designing targeted in vivo studies and comparative analyses to evaluate readouts from individual components or to determine optimal sequencing of combinatorial NAMs arranged in series or parallel. The testing conditions intended for your NAM can be directly assessed in in vivo systems such as wild-type, knockout, or humanized mice, ensuring that data generated are biologically grounded and translationally relevant.

All project information and data generated through these services remain confidential and are the exclusive property of the requesting investigator, ensuring complete protection of intellectual property. NAM Co-Development Services accelerate the creation of functionally validated, biologically aligned NAMs ready for application in biomedical research and regulatory approval.

Benefits of working with us:

• Seamless integration with Verification and Validation Services, ensuring your NAM progresses efficiently from design to research application to regulatory-ready performance benchmarking.
• Collaborative access to UC Davis expertise in physiology, mechanistic biology, and translational model design, bridging in vitro and in vivo comparative analysis.
• Early detection of design and biological misalignments, reducing R&D costs and timelines through informed, data-driven optimization.
• Assurance of scientific rigor, reproducibility, and data integrity, supported by established protocols and quality systems that align with NAM functionality and regulatory standards.

Questions about enhancing your NAM with in vivo biological context? Contact us.